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Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate high resolution crystal structures and the synthesis of new inhibitors. Towards new antifolates targeting eukaryotic agents targeting Candida glabrata dihydrofolate.
Probing the active site of Candida glabrata dihydrofolate reductase with reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance. If you identify any major please sign in and mark the publication list, please let us know.
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